European Heart Journal Open

Exploring the link between Gilbert's syndrome and atherosclerotic cardiovascular disease: insights from a subpopulation-based analysis of over one million individuals

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Gilbert’s syndrome (GS) is a mild liver condition, characterized by impaired ability to process bilirubin.1 Its prevalence ranges from 0.5% to 10%, depending on the population.2 Studies have shown that individuals with GS have a lower risk of atherosclerotic cardiovascular disease (ASCVD).3–5 However, no systematic comparison across different subgroups has been conducted. Using a large electronic health record (EHR), we measured the effect of GS on incident ASCVD events by age, race, and sex subgroups. Our findings highlight protection effect of GS varies among different subgroups.