Consider a sequential process in which each step outputs a system Ai and updates a side information register E. We prove that if this process satisfies a natural "non-signalling" condition between past outputs and future side information, the min-entropy of the outputs A1,…,An conditioned on the side information E at the end of the process can be bounded from below by a sum of von Neumann entropies associated with the individual steps. This is a generalisation of the entropy accumulation theorem (EAT), which deals with a more restrictive model of side information: there, past side information cannot be updated in subsequent rounds, and newly generated side information has to satisfy a Markov condition. Due to its more general model of side-information, our generalised EAT can be applied more easily and to a broader range of cryptographic protocols. As examples, we give the first multi-round security proof for blind randomness expansion and a simplified analysis of the E91 QKD protocol. The proof of our generalised EAT relies on a new variant of Uhlmann's theorem and new chain rules for the Renyi divergence and entropy, which might be of independent interest.