Publication
Journal of Biomedical Informatics
Paper

Adverse drug event detection using reason assignments in FDA drug labels

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Abstract

Adverse drug events (ADEs) are unintended incidents that involve the taking of a medication. ADEs pose significant health and financial problems worldwide. Information about ADEs can inform health care and improve patient safety. However, much of this information is buried in narrative texts and needs to be extracted with Natural Language Processing techniques, in order to be useful to computerized methods. ADEs can be found on drug labels, contained in the different sections such as descriptions of the drug's active components or more prominently in descriptions of studied side-effects. Extracting these automatically could be useful in triaging and processing drug reports. In this paper, we present three base methods consisting of a Conditional Random Field (CRF), a bi-directional Long Short Term Memory unit with a CRF layer (biLSTM+CRF), and a pre-trained Bi-directional Encoder Representations from Transformers (BERT) model. We also present several ensembles of the CRF and biLSTM+CRF methods for extracting ADEs and their Reason from FDA drug labels. We show that all three methods perform well on our task, and that combining the models through different ensemble methods can improve results, providing increases in recall for the majority class and improving precision for all other classes. We also show the potential of framing ADE extraction from drug labels as a multi-class classification task on the Reason, or type, of ADE.

Date

01 Oct 2020

Publication

Journal of Biomedical Informatics

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