Deduplication in storage systems has gained momentum recently for its capability in reducing data footprint. However, deduplication introduces challenges to storage management as storage objects (e.g., files) are no longer independent from each other due to content sharing between these storage objects. In this paper, we present a graph-based framework to address the challenges of storage management due to deduplication. Specifically, we model content sharing among storage objects by content sharing graphs (CSG), and apply graph-based algorithms to two real-world storage management use cases for deduplication-enabled storage systems. First, a quasi-linear algorithm was developed to partition deduplication domains with a minimal amount of deduplication loss (i.e., data replicated across partitioned domains) in commercial deduplication-enabled storage systems, whereas in general the partitioning problem is NP-complete. For a real-world trace of 3 TB data with 978 GB of removable duplicates, the proposed algorithm can partition the data into 15 balanced partitions with only 54 GB of deduplication loss, that is, a 5% deduplication loss. Second, a quick and accurate method to query the deduplicated size for a subset of objects in deduplicated storage systems was developed. For the same trace of 3 TB data, the optimized graph-based algorithm can complete the query in 2.6 s, which is less than 1% of that of the traditional algorithm based on the deduplication metadata. © 2012 by the authors.