For multilevel cell (MLC) phase change memory (PCM), resistance drift (R-drift) phenomenon causes cell resistance to increase with time, even at room temperature. As a result, the fixed-threshold-retention (FTR) raw-bit-error-rate (RBER) surpasses practical ECC correction ability within hours after being programmed. This study proposes a resistance drift compensation (RDC) scheme to mitigate R-drift issue. The proposed RDC scheme realizes PCM drift compensation and features RDC pulse to suppress ECC decoding failure. The proposed approach was validated using a 90-nm 128M cells PCM chip and an FPGA-based memory controller verification system. The MLC PCM FTR RBER has been suppressed by over 100×, thereby bringing it within ECC capability. The effectiveness of the RDC scheme was verified up to 106 cycles.