Victor W. L. Ng, Julian M. W. Chan, et al.
Advanced Drug Delivery Reviews
In this article, we develop a mathematical model for the rotary bacterial flagellar motor (BFM) based on the recently discovered structure of the stator complex (MotA5MotB2). The structure suggested that the stator also rotates. The BFM is modeled as two rotating nano-rings that interact with each other. Specifically, translocation of protons through the stator complex drives rotation of the MotA pentamer ring, which in turn drives rotation of the FliG ring in the rotor via interactions between the MotA ring of the stator and the FliG ring of the rotor. Preliminary results from the structure-informed model are consistent with the observed torque-speed relation. More importantly, the model predicts distinctive rotor and stator dynamics and their load dependence, which may be tested by future experiments. Possible approaches to verify and improve the model to further understand the molecular mechanism for torque generation in BFM are also discussed.
Victor W. L. Ng, Julian M. W. Chan, et al.
Advanced Drug Delivery Reviews
Jesus J. Caban, Noah Lee, et al.
ISBI 2009
James R. Schwank, Marty R. Shaneyfelt, et al.
RADECS 2011
Alexandre Andrade Loch, Ana Caroline Lopes-Rocha, et al.
JMIR Mental Health