In this paper, we investigate the highly reliable subgraph problem, which arises in the context of uncertain graphs. This problem attempts to identify all induced subgraphs for which the probability of connectivity being maintained under uncertainty is higher than a given threshold. This problem arises in a wide range of network applications, such as protein-complex discovery, network routing, and social network analysis. Since exact discovery may be computationally intractable, we introduce a novel sampling scheme which enables approximate discovery of highly reliable subgraphs with high probability. Furthermore, we transform the core mining task into a new frequent cohesive set problem in deterministic graphs. Such transformation enables the development of an efficient two-stage approach which combines novel peeling techniques for maximal set discovery with depth-first search for further enumeration. We demonstrate the effectiveness and efficiency of the proposed algorithms on real and synthetic data sets. Copyright 2011 ACM.