Satoshi Hada
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences
Unequal cell division, leading to daughter cells of different sizes, is a common event during development. We have formulated a model that shows how different cell sizes can lead to significant differences in the expression of an activator gene. The model is based on well-known aspects of the regulation of gene expression, specifically the existence of multiple regulatory sites, positive autoregulation, and the short half-life of regulatory proteins. Thus the daughter cells may follow distinct differentiation pathways even if there were no localized determinants in the mother cell. © 1995 Academic Press. All rights reserved.
Satoshi Hada
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences
Martin C. Gutzwiller
Physica D: Nonlinear Phenomena
Ziv Bar-Yossef, T.S. Jayram, et al.
Journal of Computer and System Sciences
Jaione Tirapu Azpiroz, Alan E. Rosenbluth, et al.
SPIE Photomask Technology + EUV Lithography 2009