Towards automated and marker-less parkinson disease assessment: Predicting updrs scores using sit-stand videos

Abstract

This paper presents a novel deep learning enabled, video based analysis framework for assessing the Unified Parkinson's Disease Rating Scale (UPDRS) that can be used in the clinic or at home. We report results from comparing the performance of the framework to that of trained clinicians on a population of 32 Parkinson's disease (PD) patients. In-person clinical assessments by trained neurologists are used as the ground truth for training our framework and for comparing the performance. We find that the standard sit-to-stand activity can be used to evaluate the UPDRS sub-scores of bradykinesia (BRADY) and posture instability and gait disorders (PIGD). For BRADY we find Fl-scores of 0.75 using our framework compared to 0.50 for the video based rater clinicians, while for PIGD we find 0.78 for the framework and 0.45 for the video based rater clinicians. We believe our proposed framework has potential to provide clinically acceptable end points of PD in greater granularity without imposing burdens on patients and clinicians, which empowers a variety of use cases such as passive tracking of PD progression in spaces such as nursing homes, in-home self-assessment, and enhanced tele-medicine.