Lexical Semantic Change (LSC) detection, also known as Semantic Shift, is the process of identifying and characterizing variations in language usage across different scenarios such as time and domain. It allows us to track the evolution of word senses, as well as to understand the difference between the languages used by distinct communities. LSC detection is often done by applying a distance measure over vectors of two aligned word embedding matrices. In this paper, we present SenSE, an interactive semantic shift exploration toolkit that provides visualization and explanation of lexical semantic change for an input pair of text sources. Our system focuses on showing how the different alignment strategies may affect the output of an LSC model as well as on explaining semantic change based on the neighbors of a chosen target word, while also extracting examples of sentences where these semantic deviations appear. The system runs as a web application (available at http://sense.mgruppi.me), allowing the audience to interact by configuring the alignment strategies while visualizing the results in a web browser.