Error mitigation has emerged as a crucial ingredient in near-term, noisy quantum computation. Although quantum error correction is ultimately required to indefinitely extend the computation time, improvements in hardware will further enhance the reach and efficacy of error mitigation techniques. In this talk, I will highlight recent advances in fixed-frequency quantum processors and discuss related challenges for techniques such as zero-noise extrapolation. Ultimately, for these techniques to be valuable, they need to enable quantum computation that is competitive against relevant approximate classical techniques. In this context, I will discuss our recent experiments that suggest that these devices could be an attractive platform for the exploration of non-equilibrium many-body physics. This talk will discuss work from arXiv:2108.09197, arXiv:2106.00675 and arXiv:2105.15201.