Review of Scientific Instruments

Photoionization mass spectrometer with a microscope laser desorption source

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An apparatus is been described in which laser desorption, separate laser ionization, mass spectrometry, and microscopy are combined. An UV waveguide laser is focused on a sample, which is mounted on translation stages in vacuum. Desorbed neutral molecules are ionized above the surface by a second laser, and ions are extracted into a reflectron time of flight mass spectrometer. A spatial resolution of 1 μm is demonstrated, with a mass resolution of 2000 and a detection efficiency of 10-4.