Notiz zur Synthese Eines Optisch Aktiven Ace‐Hemmers mit Amino‐oxo‐benzazepin‐1‐alkansäure‐Struktur mittels enantiokonvergierender kristallisationsinduzierter Racemat‐Trennung

Abstract

Note on the Synthesis of an Optically Active ACE Inhibitor with Amino‐oxo‐benzazepine‐1‐alkanoic‐Acid Structure by Means of an Enantioconvergent Crystallization‐Based Resolution An enantioselective synthesis of the potent angiotensin‐converting enzyme inhibitor (1′S,3S)‐3‐[(1′‐(ethoxy‐carbonyl)‐3′‐phenylpropyl)amino]‐2,3,4,5‐tetrahydro‐2‐oxo‐1H‐1‐benzazepine‐1‐acetic acid hydrochloride (3) is described which user a crystallization‐based resolution of a racemic amino intermediate with concomitant racemization of the unwanted enantiomer. Copyright © 1988 Verlag GmbH & Co. KGaA, Weinheim