Robert W. Keyes
Physical Review B
Note on the Synthesis of an Optically Active ACE Inhibitor with Amino‐oxo‐benzazepine‐1‐alkanoic‐Acid Structure by Means of an Enantioconvergent Crystallization‐Based Resolution An enantioselective synthesis of the potent angiotensin‐converting enzyme inhibitor (1′S,3S)‐3‐[(1′‐(ethoxy‐carbonyl)‐3′‐phenylpropyl)amino]‐2,3,4,5‐tetrahydro‐2‐oxo‐1H‐1‐benzazepine‐1‐acetic acid hydrochloride (3) is described which user a crystallization‐based resolution of a racemic amino intermediate with concomitant racemization of the unwanted enantiomer. Copyright © 1988 Verlag GmbH & Co. KGaA, Weinheim