Rapid Lexical Alignment to a Conversational Agent
Rachel Ostrand, Victor S. Ferreira, et al.
INTERSPEECH 2023
The prospective study of youths at clinical high risk (CHR) for psychosis, including neuroimaging, can identify neural signatures predictive of psychosis outcomes using algorithms that integrate complex information. Here, to identify risk and psychosis conversion, we implemented multiple kernel learning (MKL), a multimodal machine learning approach allowing patterns from each modality to inform each other. Baseline multimodal scans (n = 74, 11 converters) included structural, resting-state functional imaging, and diffusion-weighted data. Multimodal MKL outperformed unimodal models (AUC = 0.73 vs. 0.66 in predicting conversion). Moreover, patterns learned by MKL were robust to training set variations, suggesting it can identify cross-modality redundancies and synergies to stabilize the predictive pattern. We identified many predictors consistent with the literature, including frontal cortices, cingulate, thalamus, and striatum. This highlights the advantage of methods that leverage the complex pathophysiology of psychosis.
Rachel Ostrand, Victor S. Ferreira, et al.
INTERSPEECH 2023
Jenna M. Reinen, Alexis E. Whitton, et al.
European Neuropsychopharmacology
Daiki Kimura, Naomi Simumba, et al.
MIRU 2024
Kahn Rhrissorrakrai, Filippo Utro, et al.
Briefings in Bioinformatics