Modeling hippocampal circuitry using data from whole cell patch clamp and dual intracellular recordings in vitro

Abstract

In vitro hippocampal slice preparations generate a variety of neuronal behaviors involving populations of 1000 neurons or more. Understanding population behavior requires information on single neuron electrophysiology, synoptic connectivity and the properties of different kinds of individual synapses. We describe a model that incorporates these diverse types of data. The model can account for several epileptic behaviors and EEG-like waves. © 1992.