John M. Prager, Jennifer J. Liang, et al.
AMIA Joint Summits on Translational Science 2017
MicroRNA (miRNA) are a class of non-coding RNA that suppress gene expression by degradation or translational inhibition of target RNA. Several miRNA have been shown to target oncogenes and recently miRNA-125b was shown to translationally and transcriptionally inhibit the p53 gene. Here, we show that an additional isomer of miRNA-125 (miRNA-125a) translationally arrests mRNA of the p53 tumor suppressor gene. The basis of this activity is the high degree of sequence homology between the seed sequence of miR-125a and the 3′-UTR of p53. Our findings add miRNA-125a to the growing list of miRNA with oncogenic targets. © 2009 Federation of European Biochemical Societies.
John M. Prager, Jennifer J. Liang, et al.
AMIA Joint Summits on Translational Science 2017
Andreana Gomez, Sergio Gonzalez, et al.
Toxics
Yan Chen, Joachim D. Müller, et al.
Methods: A Companion to Methods in Enzymology
Federica Sotgia, Diana Whitaker-Menezes, et al.
Cell Cycle