Making the most of it: Pathway reconstruction and integrative simulation using the data at hand

Pathway reconstruction is a fundamental task in systems biology toward an ultimate goal of full-scale in silico simulations. The data for such reconstructions is mostly lacking, but collection is underway for some model organisms. However, biological specificity might limit the ability to extrapolate findings. High-throughput data and methods might alleviate these problems, but only coarse or limited reconstructions are now possible. Inclusion of multiple data sources may improve the situation but remains a challenge.