The chemical and petroleum (oil and gas, C&P) is a fast growing and diversified industry. Various applications, from field technique equipment data exchange to business execution with Enterprise Resource Planning (ERP) system, have been deployed to manage and record operation performance. Various industry standards have been defined to create a commonly accepted nomenclature for representing structural and operational aspects of oil and gas enterprises. All of these industry standards represent valuable sources of information and industry best practice, which is accepted by large community and helps enterprise building IT systems in flexible and interoperable way. However, the overlaps and gaps between standards bring inconsistency for implementation. This article introduces Reference Semantic Model (RSM), a key component of IBM C&P solution and basis of C&P integration framework, which pull together concepts from various standards using a semantic modeling approach, fill gaps and build bridge between the standards, and presents a uniform information model with rich context quantity for C&P enterprises. It then brought up a RSM based model driven integration solution for solving typical C&P system integration problem, which is flexible, interoperable and standards implemented. © 2010 IEEE.