Publication
Journal of Molecular Graphics
Paper

Electrostatic potential and binding of drugs to the minor groove of DNA

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Abstract

The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity. © 1987.

Date

01 Jan 1987

Publication

Journal of Molecular Graphics

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