Using a television-rate, digital image processing system, a number of applications areas for electron microscopy have been developed for high-speed performance. The main component of the system is a digital television frame store which is linked to a large mainframe computer. Many features of the frame store such as digitization, zoom and pan, arithmetic and Boolean processors, image video routing, lookup table modification and histogram generation can be performed rapidly from menu-driven software. It is the purpose of this paper to describe methods whereby high-speed image creation, acquisition, manipulation and measurements can be made using the above mentioned frame store functions as opposed to the images being processed or modified on the host computer. Examples will be given in the areas of multiple image digitization, optimal imaging determination via gray-level histograms, contrast correction and compression, particle analysis and Fourier analysis. © 1985.