Abstract
Massively-parallel, integrated, sensitive and low-cost bio-molecular detectors are an essential part of "next generation" DNA sequencing systems. This paper discusses various design methodologies that leverage the versatility of VLSI technologies, specifically CMOS fabrication processes, to build highly integrated sequencing arrays while addressing the stringent detection and integration requirements. The goal of this paper is to discuss both the advantages and the limitations of next generation VLSI-enabled DNA sequencers. © 2011 IEEE.