Publication
Journal of Organic Chemistry
Paper

The Generation and Rearrangement of 2-(Diazoacetyl)cyclobutanones: The Formation of 5-Spirocyclopropyl-2(5H)-furanones

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Abstract

We describe here a simple synthesis of 2-(diazoacetyl)cyclobutanones and their facile thermal rearrangement to 5-spirocyclopropyl-Δα,β-butenolides. The yield of the rearrangement product is high, and the reaction is completely stereospecific. α-Ketenylcyclobutanones have been identified spectroscopically as intermediates, and their rearrangement was studied kinetically. A strained dipolar cyclic transition is proposed for the rearrangement of the α-ketenylcyclobutanones to the corresponding 5-spirocyclopropyl-Δα,β-butenolides. © 1991, American Chemical Society. All rights reserved.

Date

01 May 2002

Publication

Journal of Organic Chemistry

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