The ever increasing sophistication in IT services demands to consider dynamic and large-scale deployments in distributed environments built on top of federated public and private Clouds. Unfortunately, in these complex hybrid Cloud environments, it is extremely difficult to estimate the impact of even simple reconfigurations of the IT service architecture before enacting them. There is the need for new service management tools that are capable of exploring alternative IT service architectures, of accurately evaluating them to find out the most convenient one, and of reconfiguring the IT service accordingly. This paper presents Business-Driven Management as a Service Plus (BDMaaS+), that significantly evolves our previous work to consider the business-driven evaluation of IT services in hybrid Cloud environment, advanced IT service models that complex multi-tier workflows, and realistic network models. The experimental evaluation of BDMaaS+ to optimize a realistic large-scale IT service demonstrates that our tool is capable of finding a more convenient configuration that significantly reduce the total daily costs while granting at the same time agreed service levels.