Quantum Computing has made tremendous progress in recent years, including the quality and quantity of qubits in a quantum processor. To solve large scale problems on a quantum computer and realize its full potential, quantum error correction (QEC) will likely be needed. Unfortunately, QEC requires significant overhead of several orders of magnitude, which won't be available near term. Taking a more scalable path to implement high fidelity quantum circuits and achieve quantum advantage, where a scientifically or business-relevant task can be computed more efficiently, cost effectively, or accurately on a quantum computer, less quantum resource intense approaches can be utilized, such as error mitigation and circuit knitting techniques. While further quantum hardware improvements always help, quantum and classical processors need to be seamlessly integrated in the software stack to exploit these techniques. We call the resulting system a quantum-centric supercomputer, which I will discuss in this talk.