Despite the continued advances of digital computing including accelerators for artificial intelligence, there are still many important and relevant mathematical problems that are intractable for classical computers. Quantum Computers are a radically different approach and open a new trajectory to evolve computation and enable solving difficult and complex problems. In the past years significant progress has been made toward understanding the scope of quantum computing, pushing its hardware and software technology, developing applications, and advancing error mitigation/correction protocols. An entire new computing system is built from the bottom up. Advancing the state-of-the-art as quickly as possible requires pursuing in parallel improvements in three key metrics - scale, quality, and speed of quantum systems, as well as simultaneously providing advanced capabilities to exploit the performance and make them easy to use. Integrating new technologies such as advanced packaging, high-density control signal delivery, developing advanced qubit control electronics have already enabled scaling of superconducting quantum processors to 433-qubits. Combined with increases in quality and speed this has driven significant improvements in the performance of quantum computers. Moreover, the computational capabilities of today’s quantum hardware can be extended by tight integration of quantum and classical resources using techniques like circuit knitting to accelerate the path towards quantum advantage. Developing approaches to connect individual quantum processors in various ways with classical as well as quantum communication links enables a modular approach to further scale quantum systems.