Kyle Ellrott, Alex Buchanan, et al.
Genome Biology
We present the concept of a nanoelectromechanical device capable of controlling the position of DNA inside a nanopore with a single nucleotide accuracy. The device utilizes the interaction of discrete charges along the backbone of a DNA molecule with the electric field inside the nanopore. In analogy to solid state transistors in which a small voltage controls the current between two electrodes, a voltage strategically located inside the nanopore can control the translocation of a single DNA molecule between a cis and a trans reservoirs. We propose an immediate application of the device as a replacement of capillary electrophoresis in DNA sequencing. © 2007 American Institute of Physics.
Kyle Ellrott, Alex Buchanan, et al.
Genome Biology
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PLoS ONE
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JAMA network open
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Advanced Materials Technologies