Wesam Alramadeen, Yu Ding, et al.
IISE Transactions on Healthcare Systems Engineering
Background: Emergence of vaccine-escaping SARS-CoV-2 variants is a serious problem for global public health. The currently rampant Omicron has been shown to possess remarkable vaccine escape; however, the selection pressure exerted by vaccines might pave the way for other escape mutants in the near future. Materials & methods: For detection of neutralizing antibodies, the authors used the recently developed HiBiT-based virus-like particle neutralization test system. Sera after vaccination (two doses of Pfizer/BioNTech mRNA vaccine) were used to evaluate the neutralizing activity against various strains of SARS-CoV-2. Results: Beta+R346K, which was identified in the Philippines in August 2021, exhibited the highest vaccine resistance among the tested mutants. Surprisingly, Mu+K417N mutant exhibited almost no decrease in neutralization. Imdevimab retained efficacy against these strains. Conclusions: Mutations outside the receptor-binding domain contributed to vaccine escape. Both genomic surveillance and phenotypic analysis synergistically accelerate identifications of vaccine-escaping strains.
Wesam Alramadeen, Yu Ding, et al.
IISE Transactions on Healthcare Systems Engineering
T.L. Fabry, C. Simo, et al.
BBA - Protein Structure
Keith Lloyd, Matteo Cella, et al.
BMC Medical Informatics and Decision Making
Esraa Omran, Tyrone Grandison, et al.
World Congress on Medical Informatics 2010