Ashlynn L.Z. Lee, Zhi Xiang Voo, et al.
ACS AMI
Aim: Phenformin-loaded micelles (Phen M) were used in combination with gemcitabine-loaded micelles (Gem M) to study their combined effect against H460 human lung cancer cells and cancer stem cells (CSCs) in vitro and in vivo. Materials & methods: Gem M and Phen M were prepared via self-assembly of a mixture of a diblock copolymer of PEG and urea-functionalized polycarbonate (PEG-PUC) and a diblock copolymer of PEG and acid-functionalized polycarbonate (PEG-PAC) through hydrogen bonding and ionic interactions. Gem M and Phen M were characterized and tested for efficacy both in vitro and in vivo against cancer cells and CSCs. Results: The combination of Gem M/Phen M exhibited higher cytotoxicity against CSCs and non-CSCs than Gem M and Phen M alone, and showed significant cell cycle growth arrest in vitro. The combination therapy had superior tumor suppression and apoptosis in vivo without inducing toxicity to liver and kidney. Conclusion: The combination of Gem M and Phen M may be potentially used in lung cancer therapy.
Ashlynn L.Z. Lee, Zhi Xiang Voo, et al.
ACS AMI
Chuan Yang, Ashlynn L.Z. Lee, et al.
Journal of Controlled Release
Ashlynn L. Z. Lee, Victor W. L. Ng, et al.
Biomaterials
Jeremy P. K. Tan, Zhi Xiang Voo, et al.
Nanomedicine: NBM