COVID-19 resulted in massive human casualties and an economic collapse across the globe. To prepare for the future, this Forum introduces the key challenges with detection and prevention of pandemics and highlights some potential opportunities for employing silicon technologies to quickly diagnose, treat, and prevent diseases. IC technologies that enable point-of-care diagnostics, continuous health monitoring, and lab-on-chip RNA detection continue to revolutionize healthcare. Further, high-performance computing (HPC) accelerates drug discovery, vaccine development, as well as real-time tracking of the spread of diseases and their socio-economic impacts. This Forum will address a wide spectrum of topics at the intersection of circuit/system design and bio-engineering.